TTP’s proprietary Puckdx platform offers a flexible, fast time-to-result and low-cost solution for translating diagnostic assays for human and animal health … “We are excited to have such a major diagnostic company wishing to bring the platform to market for human applications.

The coupling allows the instrument to rotate the pipette about the central axis and then lower it to collect fluids from different chambers in the cartridge base. With only one moving part, the Puckdx system is inherently dependable and relies on a self-centring movement of the robotic pipette arm as it’s lowered to form the fluid connection with the dip tube.

The coupling allows the instrument to rotate the pipette about the central axis and then lower it to collect fluids from different chambers in the cartridge base. Flexible, low-cost translation of diagnostic assays to a simple, easy-to-use device, BotDetect CAPTCHA ASP.NET Form Validation. Technology hothouse TTP is at the heart of a European initiative to revolutionise in vitro diagnostic medical device (IVD) technology to boost healthcare options.

They could include: diagnostic testing, testing of food and drink samples, paint colour matching, multi-part adhesive mixing, bespoke blending of perfumes, food flavourings and colourings, or perhaps even the preparation of elaborate blends for coffee connoisseurs. Clean wash buffer can then be added, the magnet removed, and the beads suspended to help purify the DNA. Puckdx can currently complete 40 PCR cycles in around 10 mins.

The DNA sticks to the ferrous beads, and a mechanism in Puckdx raises two magnets to capture the beads on a side wall whilst the waste fluid is removed via the pipette. The 50 hottest disruptive technology companies. DiaSorin will utilise TTP’s Puckdx platform for human in vitro diagnostic assays Cambridge, UK, and Saluggia, Italy, 02 March 2020: TTP plc (TTP), a leading independent technology and product development company, and DiaSorin, a global leader in the in vitro diagnostic (IVD) field, have signed an exclusive licence and technology transfer agreement. TTP’s Puckdx is based on a unique disposable robotic pipette system with a fast PCR module, combined with a cartridge containing all the necessary reagents. Some diagnostic applications, PCR for example, require the use of coated ferrous beads to extract and purify DNA for analysis. Cambridge, UK, and Saluggia, Italy: TTP plc, a leading independent technology and product development company, and DiaSorin, a global leader in the in vitro diagnostic (IVD) field, have signed an exclusive licence and technology transfer agreement. TTP’s proprietary Puckdx platform offers a flexible, fast time-to-result and low-cost solution for translating diagnostic assays for human and animal health and life science research to an easy-to-use desktop device. A fixed dip tube in each of the cone-shaped fluid chambers means that the pipette can reach the bottom of the tapered V-shaped floor to effectively extract fluids. The engineers at TTP, one of Europe’s leading independent product and technology development companies faced this challenge when they set out to develop new technology that would enable diagnostic assays to be performed at the point of care (POC)—i.e., in doctor’s surgeries or at the patient’s bedside. Taking advantage of its culture of freedom to pursue internal developments as well as its expertise in product development, TTP developed Puckdx, a flexible, low-cost solution for translating diagnostic assays to a simple, easy-to-use desktop device. And that’s where the engineering simplicity comes in: A central shaft is raised to mechanically and pneumatically engage with a movable pipette, the only moving part within the cartridge. For PCR-based diagnostic applications, the challenges of rapidly heating and cooling microlitres of fluid while at the same time optically interrogating the sample were overcome by building a microfluidic chamber that is thin enough to be thermally reactive but thick enough to allow excitation of fluorescent biomarkers via LEDs to one side. And, all things being equal, it was felt that the lowest cost system has the potential to become the market leader.Many POC systems comprise a consumable cartridge and an easy-to-use instrument small enough to fit on a worktop in a doctor’s surgery. The opportunity to utilise Puckdx for other fields of application continues to be available and we would be keen to collaborate with key players developing  assays in areas such as for animal health and low-cost lab robotics.". Cambridge Network Limited is a company registered in England under company No.

Using this simple and cost-effective technology solution in combination with DiaSorin’s human IVD assays could … In which applications could a simple, low-cost robotic system that performs on-site, precise fluid mixing and manipulation be used? As it engages each chamber, a spike pierces the foil to prevent air locks as fluid is aspirated or dispensed. This wash process can be repeated.Other systems use one magnet to capture the beads, but Puck utilises two to create a strong magnetic field on the side walls of the chamber.

DiaSorin will combine its extensive molecular test offering with TTP’s Puckdx™ platform to develop a single-use, sample-to-answer, molecular diagnostics point-of-care platform for human IVD applications. Stay informed of the latest news and features. DiaSorin estimates that the first test on this platform will be made commercially available in the US by 2023. One-off usage is permitted but bulk copying is not. Using this simple and cost-effective technology solution in combination with DiaSorin’s human IVD assays could provide clients with a result in less than 15 minutes. POC diagnostic testing systems typically enable rapid, low-cost, and de-skilled diagnostic testing in medical centres for, say, a range of infectious diseases and thus compete with off-site clinical laboratories. The biological sample to be tested, or other material to be processed, is introduced into the cartridge, which is then inserted into the Puckdx instrument about the size of a small coffee machine (75 x 150 x 200mm). TTP’s Puckdx platform is based on a unique disposable robotic pipette system with a fast PCR module, combined with an easy-to-use cartridge containing all the necessary reagents. Business Weekly is a trademark of Q Communications Ltd. Italian pioneer works with TTP to boost global health diagnostics, Cambridge-Sydney alliance advances promising cancer immunotherapy, Cambridge-Swiss alliance produces new microfluidic driver, Perfect STORM as partners explore role of RNA epigenetics in epilepsy, Crescendo enters collaboration to create cutting-edge oncology treatment, Medical alliance to advance technology push.

For further information about TTP’s Puckdx platform, please visit:  https://www.ttp.com/desktop-biology. This material is protected by MA Business copyright An even quicker design, using a thin film heater, is being developed and should reduce this to 3 minutes. The opportunity to utilise Puckdx for other fields of application continues to be available and we would be keen to collaborate with key players developing assays in areas such as for animal health and low-cost lab robotics.”. Eureka is the site for engineering design.

The DNA sticks to the ferrous beads, and a mechanism in Puckdx raises two magnets to capture the beads on a side wall whilst the waste fluid is removed via the pipette. Beyond that, TTP emphasised flexibility, since platforms that can run several types of diagnostic tests in the rapidly expanding POC diagnostic market are likely to have the edge. Giles Sanders, consultant at TTP plc said: “We are delighted that DiaSorin has chosen Puckdx as their preferred POC platform. sales team. The Puckdx cartridge is slightly larger than a coffee pod and has pre-filled foil-sealed chambers to store fluids, in particular reagents for diagnostic assays, but potentially also other ingredients for other applications.

And, all things being equal, it was felt that the lowest cost system has the potential to become the market leader. © 2020 Business Weekly All rights reserved.

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